Methyl iodide → Ethyl 1-benzyl-4-methylpiperazine-2-carboxylate

HRID 524778Notes

Reaction equation

HRID 524778 reaction equation
[CH2:1]([N:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH:9]1[C:14]([O:16][CH2:17][CH3:18])=[O:15])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.I[CH3:20]>>[CH2:1]([N:8]1[CH2:13][CH2:12][N:11]([CH3:20])[CH2:10][CH:9]1[C:14]([O:16][CH2:17][CH3:18])=[O:15])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 10682021Ethyl 1-benzylpiperazine-2-carboxylate

Product 1

HCID 10563447Ethyl 1-benzyl-4-methylpiperazine-2-carboxylateYield 73%

Procedure

Ethyl 1-benzylpiperazine-2-carboxylate (3.03 g, 12.2 mmol) was reacted with iodomethane (1.73 g, 12.2 mmol) according to the procedure as described in Example 48, Step A to give the title compound as yellow oil (2.33 g, 73%). The compound was characterized by the following spectroscopic data:

Sources & evidence

ORD record
ord-99866f51bb00415ca373b5085a1e30b6
Source dataset
uspto-grants-2016_05
Patent number
US09340538B2

Reaction notes

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