Sodium Hydroxide → 4-Methylpiperazine-2-carboxylic acid

HRID 524780Notes

Reaction equation

[CH3:1][N:2]1[CH2:7][CH2:6][NH:5][CH:4]([C:8]([O:10]CC)=[O:9])[CH2:3]1.[OH-].[Na+]>>[CH3:1][N:2]1[CH2:7][CH2:6][NH:5][CH:4]([C:8]([OH:10])=[O:9])[CH2:3]1

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 12558522Ethyl 4-methylpiperazine-2-carboxylate

Product 1

HCID 64209034-Methylpiperazine-2-carboxylic acidYield 100%

Procedure

Ethyl 4-methylpiperazine-2-carboxylate (1.03 g, 6 mmol) was reacted with NaOH (0.48 g, 12 mmol) according to the procedure as described in Example 21, Step A to give the title compound as colorless oil (0.86 g, 100%). The compound was characterized by the following spectroscopic data:

Sources & evidence

ORD record: ord-88397e1baa204780b98e954df8ed3c75
Source dataset: uspto-grants-2016_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09340538B2

Reaction notes

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