HCID 21183377, compound → HCID 118107569, compound

HRID 524795Notes

Reaction equation

HRID 524795 reaction equation
[Br:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[CH:9]1[C:14]([C:15]([O:17][CH2:18][CH3:19])=[O:16])=[C:13]([CH2:20]Br)[NH:12][C:11]([C:22]2[S:23][CH:24]=[CH:25][N:26]=2)=[N:10]1.[NH:27]1[CH2:32][CH2:31][O:30][CH:29]([CH2:33][CH2:34][CH2:35][OH:36])[CH2:28]1>>[Br:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[CH:9]1[C:14]([C:15]([O:17][CH2:18][CH3:19])=[O:16])=[C:13]([CH2:20][N:27]2[CH2:32][CH2:31][O:30][CH:29]([CH2:33][CH2:34][CH2:35][OH:36])[CH2:28]2)[NH:12][C:11]([C:22]2[S:23][CH:24]=[CH:25][N:26]=2)=[N:10]1

Participants

3

Reactant 2

HCID 21183377HCID 21183377, compoundHCID 59495567Ethyl 4-(2-bromo-4-fluorophenyl)-6-(bromomethyl)-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate

Product 1

HCID 118107569HCID 118107569, compoundYield 70.5%

Procedure

Ethyl 4-(2-bromo-4-fluorophenyl)-6-(bromomethyl)-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate (1.26 g, 2.5 mmol) was reacted with 3-(morpholin-2-yl)propan-1-ol (0.43 g, 3 mmol) according to the procedure as described in Example 25, Step B to give the title compound as a yellow solid (1.0 g, 70%). The compound was characterized by the following spectroscopic data:

Sources & evidence

ORD record
ord-117f671e045c444ca2c33f814d779eb0
Source dataset
uspto-grants-2016_05
Patent number
US09340538B2

Reaction notes

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