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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 524795Generated: October 30, 2026

HCID 21183377, compound → HCID 118107569, compound

https://huagongshe.com/reaction/524795

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHCID 21183377HCID 21183377—
ReactantEthyl 4-(2-bromo-4-fluorophenyl)-6-(bromomethyl)-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylateHCID 59495567—
ProductHCID 118107569HCID 11810756970.5%

Reaction Steps

Ethyl 4-(2-bromo-4-fluorophenyl)-6-(bromomethyl)-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate (1.26 g, 2.5 mmol) was reacted with 3-(morpholin-2-yl)propan-1-ol (0.43 g, 3 mmol) according to the procedure as described in Example 25, Step B to give the title compound as a yellow solid (1.0 g, 70%). The compound was characterized by the following spectroscopic data:

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09340538B2
Source datasetuspto-grants-2016_05
ORD IDord-117f671e045c444ca2c33f814d779eb0
Source noteuspto-grants-2016_05