Methylamine hydrochloride → HCID 118107592, compound

HRID 524796Notes

Reaction equation

[Br:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[CH:9]1[N:14]=[C:13]([C:15]2[S:16][CH:17]=[CH:18][N:19]=2)[NH:12][C:11]([CH2:20][N:21]2[CH2:26][CH2:25][O:24][CH:23]([CH2:27][CH2:28][C:29](O)=[O:30])[CH2:22]2)=[C:10]1[C:32]([O:34][CH2:35][CH3:36])=[O:33].Cl.[CH3:38][NH2:39]>>[Br:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[CH:9]1[C:10]([C:32]([O:34][CH2:35][CH3:36])=[O:33])=[C:11]([CH2:20][N:21]2[CH2:26][CH2:25][O:24][CH:23]([CH2:27][CH2:28][C:29]([NH:39][CH3:38])=[O:30])[CH2:22]2)[NH:12][C:13]([C:15]2[S:16][CH:17]=[CH:18][N:19]=2)=[N:14]1

Participants

Reactant 2

HCID 6364545Methylamine hydrochloride

HCID 73211784HCID 73211784, compound

Product 1

HCID 118107592HCID 118107592, compoundYield 38.2%

Procedure

3-(4-((6-(2-bromo-4-fluorophenyl)-5-(ethoxycarbonyl)-2-(thiazol-2-yl)-3,6-dihydropyrimidin-4-yl)methyl)morpholin-2-yl)propanoic acid (0.69 g, 1.19 mmol) was reacted with methanamine hydrochloride (0.12 g, 1.8 mmol) according to the procedure as described in Example 62, Step B to give the title compound as a yellow solid (0.27 g, 38%). The compound was characterized by the following spectroscopic data:

Sources & evidence

ORD record: ord-066f3ff3296e4e97968309abf2fd8344
Source dataset: uspto-grants-2016_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09340538B2

Reaction notes

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