Ammonia → HCID 20373768, compound

HRID 524797Notes

Reaction equation

HRID 524797 reaction equation
[NH:1]1[CH2:6][CH2:5][O:4][CH:3]([CH2:7][CH2:8][C:9]([O:11]C)=O)[CH2:2]1.[NH3:13]>CO>[NH:1]1[CH2:6][CH2:5][O:4][CH:3]([CH2:7][CH2:8][C:9]([NH2:13])=[O:11])[CH2:2]1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 84065206HCID 84065206, compound

Product 1

HCID 20373768HCID 20373768, compoundYield 78%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Methyl 3-(morpholin-2-yl)propanoate (0.58 g, 3.35 mmol) was reacted with a solution of NH3 in methanol (7 mol/L, 10 mL) according to the procedure as described in Example 25, Step A to give the title compound as brownish oil (0.41 g, 78%). The compound was characterized by the following spectroscopic data:

Sources & evidence

ORD record
ord-e592234e89e34abdb9f57c4fd94b7420
Source dataset
uspto-grants-2016_05
Patent number
US09340538B2

Reaction notes

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