5-Methoxy-1,3-thiazol-2-amine → 5-Methoxythiazole-2-carbonitrile

HRID 524802Notes

Reaction equation

HRID 524802 reaction equation
[CH3:1][O:2][C:3]1[S:7][C:6](N)=[N:5][CH:4]=1.[C:9]([Cu])#[N:10]>>[CH3:1][O:2][C:3]1[S:7][C:6]([C:9]#[N:10])=[N:5][CH:4]=1

Participants

3

Reactant 2

HCID 203162835-Methoxy-1,3-thiazol-2-amineHCID 178418546HCID 178418546, compound

Product 1

HCID 900443835-Methoxythiazole-2-carbonitrileYield 30%

Procedure

5-methoxythiazol-2-amine (2.6 g, 20 mmol) was reacted with CuCN (4 g, 44 mmol) according to the procedure as described in Example 61, Step A to give the title compound as brownish oil (0.84 g, 30%). The compound was characterized by the following spectroscopic data:

Sources & evidence

ORD record
ord-b60f1450e100498aa2dcb7364c0119c2
Source dataset
uspto-grants-2016_05
Patent number
US09340538B2

Reaction notes

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