5-(Trifluoromethyl)-1,3-thiazol-2-amine → 2-Thiazolecarbonitrile, 5-(trifluoromethyl)-

HRID 524807Notes

Reaction equation

HRID 524807 reaction equation
[F:1][C:2]([F:10])([F:9])[C:3]1[S:7][C:6](N)=[N:5][CH:4]=1.[C:11]([Cu])#[N:12]>>[F:1][C:2]([F:10])([F:9])[C:3]1[S:7][C:6]([C:11]#[N:12])=[N:5][CH:4]=1

Participants

3

Reactant 2

HCID 153888495-(Trifluoromethyl)-1,3-thiazol-2-amineHCID 178418546HCID 178418546, compound

Product 1

HCID 900431172-Thiazolecarbonitrile, 5-(trifluoromethyl)-Yield 47%

Procedure

5-(trifluoromethyl)thiazol-2-amine (2.52 g, 15 mmol) was reacted with CuCN (2.7 g, 30.2 mmol) according to the procedure as described in Example 61, Step A to give the title compound as oil (1.25 g, 47%). The compound was characterized by the following spectroscopic data:

Sources & evidence

ORD record
ord-60cadd2e987e4cbc99c5437df60cb443
Source dataset
uspto-grants-2016_05
Patent number
US09340538B2

Reaction notes

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