5-(Trifluoromethyl)-1,3-thiazol-2-amine → 2-Thiazolecarbonitrile, 5-(trifluoromethyl)-

Participants

Role	Name	HCID	Charge
Reactant	5-(Trifluoromethyl)-1,3-thiazol-2-amine	HCID 15388849	—
Reactant	HCID 178418546	HCID 178418546	—
Product	2-Thiazolecarbonitrile, 5-(trifluoromethyl)-	HCID 90043117	47%

Reaction Steps

5-(trifluoromethyl)thiazol-2-amine (2.52 g, 15 mmol) was reacted with CuCN (2.7 g, 30.2 mmol) according to the procedure as described in Example 61, Step A to give the title compound as oil (1.25 g, 47%). The compound was characterized by the following spectroscopic data:

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09340538B2
Source dataset	uspto-grants-2016_05
ORD ID	ord-60cadd2e987e4cbc99c5437df60cb443
Source note	uspto-grants-2016_05