Ammonium Chloride → 5-(Trifluoromethyl)thiazole-2-carboximidamide hydrochloride

HRID 524808Notes

Reaction equation

[F:1][C:2]([F:11])([F:10])[C:3]1[S:7][C:6]([C:8]#[N:9])=[N:5][CH:4]=1.C[O-].[Na+].[Cl-:15].[NH4+:16]>>[ClH:15].[F:11][C:2]([F:1])([F:10])[C:3]1[S:7][C:6]([C:8](=[NH:16])[NH2:9])=[N:5][CH:4]=1

Participants

Reactant 3

HCID 25517Ammonium Chloride

HCID 10942334Sodium Methoxide

HCID 900431172-Thiazolecarbonitrile, 5-(trifluoromethyl)-

Product 1

HCID 900421955-(Trifluoromethyl)thiazole-2-carboximidamide hydrochloride

Procedure

5-(trifluoromethyl)thiazole-2-carbonitrile (1.25 g, 7 mmol) was reacted with sodium methoxide (0.38 g, 7 mmol) and ammonium chloride (0.76 g, 14 mmol) according to the procedure as described in Example 61, Step B to give the title compound as an offwhite solid (1.3 g, 80%). The compound was characterized by the following spectroscopic data:

Sources & evidence

ORD record: ord-444054cd9d2849179f2a84f82f386ed7
Source dataset: uspto-grants-2016_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09340538B2

Reaction notes

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