HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Chloride → 5-(Trifluoromethyl)thiazole-2-carboximidamide hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Reactant | 2-Thiazolecarbonitrile, 5-(trifluoromethyl)- | HCID 90043117 | — |
| Product | 5-(Trifluoromethyl)thiazole-2-carboximidamide hydrochloride | HCID 90042195 | — |
Reaction Steps
5-(trifluoromethyl)thiazole-2-carbonitrile (1.25 g, 7 mmol) was reacted with sodium methoxide (0.38 g, 7 mmol) and ammonium chloride (0.76 g, 14 mmol) according to the procedure as described in Example 61, Step B to give the title compound as an offwhite solid (1.3 g, 80%). The compound was characterized by the following spectroscopic data:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09340538B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-444054cd9d2849179f2a84f82f386ed7 |
| Source note | uspto-grants-2016_05 |