HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-bromobutanimide → Ethyl 6-(bromomethyl)-4-(2-chlorophenyl)-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | Ethyl 4-(2-chlorophenyl)-6-methyl-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate | HCID 9841888 | — |
| Product | Ethyl 6-(bromomethyl)-4-(2-chlorophenyl)-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate | HCID 90043618 | 60% |
Reaction Steps
Ethyl 4-(2-chlorophenyl)-6-methyl-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate (10 g, 27.6 mmol) was reacted with NBS (5.41 g, 30.4 mmol) according to the procedure as described in Example 1, Step B to give the title compound as a yellow solid (7.3 g, 60%). The compound was characterized by the following spectroscopic data:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09340538B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-1a0ca87609e74e0cb8c27a77c9329c10 |
| Source note | uspto-grants-2016_05 |