Benzyl Bromide → HCID 118118264, compound

HRID 524831Notes

Reaction equation

[CH2:1]([N:8]1[C:13](=[O:14])[CH2:12][O:11][CH2:10][C@@:9]1([CH3:18])[C:15]([OH:17])=[O:16])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:19](Br)[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>>[CH2:1]([N:8]1[C:13](=[O:14])[CH2:12][O:11][CH2:10][C@@:9]1([CH3:18])[C:15]([O:17][CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)=[O:16])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 7498Benzyl Bromide

HCID 90042539HCID 90042539, compound

Product 1

HCID 118118264HCID 118118264, compoundYield 70.1%

Procedure

(S)-4-benzyl-3-methyl-5-oxomorpholine-3-carboxylic acid (2.49 g, 10 mmol) was reacted with benzyl bromide (2.05 g, 12 mmol) according to the procedure as described in Example 34, Step A to give the title compound as colorless oil (2.38 g, 70%). The compound was characterized by the following spectroscopic data:

Sources & evidence

ORD record: ord-c43df4f6051445b3ba812bd732891240
Source dataset: uspto-grants-2016_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09340538B2

Reaction notes

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