HCID 118118263, compound → HCID 90042966, compound

HRID 524833Notes

Reaction equation

HRID 524833 reaction equation
C([N:8]1[CH2:13][CH2:12][O:11][CH2:10][C@@:9]1([CH3:24])[C:14]([O:16]CC1C=CC=CC=1)=[O:15])C1C=CC=CC=1>[Pd]>[CH3:24][C@@:9]1([C:14]([OH:16])=[O:15])[CH2:10][O:11][CH2:12][CH2:13][NH:8]1

Participants

3

Reactant 1

HCID 118118263HCID 118118263, compound

Product 1

HCID 90042966HCID 90042966, compoundYield 67%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

(S)-benzyl 4-benzyl-3-methylmorpholine-3-carboxylate (3.26 g, 10 mmol) was reacted with H2 by Pd/C catalysis (10%, 0.33 g) according to the procedure as described in Example 34, Step C to give the title compound as a gray solid (0.97 g, 67%). The compound was characterized by the following spectroscopic data:

Sources & evidence

ORD record
ord-58be9cf5a34143f3aed2d71a8f64f9bc
Source dataset
uspto-grants-2016_05
Patent number
US09340538B2

Reaction notes

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