反应详情

To a solution of tert-butyl 1-thia-6-azaspiro[2.5]octane-6-carboxylate (430 mg, 1.875 mmol) in THF (5 mL) was added LiAlH4 (Lithium Ion (1)) (0.9375 mL of 2 M, 1.875 mmol) and the solution was stirred at room temperature for 1 h. The reaction was quenched by careful dropwise addition of water (2 ml), stirred for 10 mins before the reaction mixture was partitioned between water and EtOAc. The organic extract was washed with brine, dried (MgSO4) and concentrated to give tert-butyl 4-methyl-4-sulfanyl-piperidine-1-carboxylate as a colorless oil. (380 mg, 87%). MS (ES−) 231.0.

1. customThe reaction was quenched by careful dropwise addition of water (2 ml)
2. stirringstirred for 10 mins before the reaction mixture
3. customwas partitioned between water and EtOAc
4. extractionThe organic extract
5. washwas washed with brine
6. dry with materialdried (MgSO4)
7. concentrationconcentrated