Trifluoroacetic acid → HCID 86720966, compound

HRID 524913Notes

Reaction equation

HRID 524913 reaction equation
[CH3:1][C:2]1([S:15]([CH3:18])(=[O:17])=[O:16])[CH2:7][CH2:6][N:5](C(OC(C)(C)C)=O)[CH2:4][CH2:3]1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH3:1][C:2]1([S:15]([CH3:18])(=[O:17])=[O:16])[CH2:3][CH2:4][NH:5][CH2:6][CH2:7]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86720967HCID 86720967, compound

Product 1

HCID 86720966HCID 86720966, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of tert-butyl 4-methyl-4-methylsulfonyl-piperidine-1-carboxylate (430 mg, 1.550 mmol) in DCM (10 mL) was added TFA (3 mL, 38.94 mmol) and the solution stirred at room temperature for 1 h. The reaction was concentrated and azeotroped twice with DCM to give 4-methyl-4-(methylsulfonyl)piperidine as a sticky oil that was used in next step without further purification. MS (ES+) 178.0.

Workup

  1. concentrationThe reaction was concentrated
  2. customazeotroped twice with DCM

Sources & evidence

ORD record
ord-19e6fcc523534262aba5141f6eba8e26
Source dataset
uspto-grants-2016_05
Patent number
US09340546B2

Reaction notes

Loading…