Trifluoroacetic acid → HCID 86720979, compound

HRID 524926Notes

Reaction equation

HRID 524926 reaction equation
[NH2:1][C:2]1[C:11]([C:12]([NH:14][C:15]2[CH:16]=[N:17][CH:18]=[C:19]([F:42])[C:20]=2[N:21]2[CH2:26][CH2:25][CH:24]([C:27]([N:29]3[CH2:34][CH2:33][N:32](C(OC(C)(C)C)=O)[CH2:31][CH2:30]3)=[O:28])[CH2:23][CH2:22]2)=[O:13])=[C:5]2[N:6]=[CH:7][C:8]([F:10])=[CH:9][N:4]2[N:3]=1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[NH2:1][C:2]1[C:11]([C:12]([NH:14][C:15]2[CH:16]=[N:17][CH:18]=[C:19]([F:42])[C:20]=2[N:21]2[CH2:26][CH2:25][CH:24]([C:27]([N:29]3[CH2:30][CH2:31][NH:32][CH2:33][CH2:34]3)=[O:28])[CH2:23][CH2:22]2)=[O:13])=[C:5]2[N:6]=[CH:7][C:8]([F:10])=[CH:9][N:4]2[N:3]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86720980HCID 86720980, compound

Product 1

HCID 86720979HCID 86720979, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

tert-butyl 4-(1-(3-(2-amino-6-fluoropyrazolo[1,5-a]pyrimidine-3-carboxamido)-5-fluoropyridin-4-yl)piperidine-4-carbonyl)piperazine-1-carboxylate prepared using procedure similar to Example 4 was dissolved in a mixture of DCM (5 mL)/TFA (1 mL, 12.98 mmol) and stirred at RT for 90 min. then concentrated in vacuo. The residue was purified by fractionlynx. Clean fractions were freeze dried to yield 2-amino-6-fluoro-N-(5-fluoro-4-(4-(piperazine-1-carbonyl)piperidin-1-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide. MS (ES+) 486.2.

Workup

  1. concentrationthen concentrated in vacuo
  2. customThe residue was purified by fractionlynx
  3. customdried

Sources & evidence

ORD record
ord-47bdca73c2a842dfbeb26ccfb24e7188
Source dataset
uspto-grants-2016_05
Patent number
US09340546B2

Reaction notes

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