2,6-Dimethylaniline → HCID 85710725, compound

HRID 525026Notes

Reaction equation

HRID 525026 reaction equation
[NH:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]([OH:8])=O.[CH3:9][C:10]1[CH:16]=[CH:15][CH:14]=[C:13]([CH3:17])[C:11]=1[NH2:12]>>[CH3:9][C:10]1[CH:16]=[CH:15][CH:14]=[C:13]([CH3:17])[C:11]=1[NH:12][C:6]([C:2]1[NH:1][CH:5]=[CH:4][CH:3]=1)=[O:8]

Participants

3

Reactant 2

HCID 68962,6-DimethylanilineHCID 12473Pyrrole-2-Carboxylic Acid

Product 1

HCID 85710725HCID 85710725, compoundYield 23.3%

Procedure

The title compound was prepared from 1H-pyrrole-2-carboxylic acid (2 g, 18 mmol) and 2,6-dimethylaniline (2.75 g, 22.7 mmol) following the experimental procedure described in Preparation 44a. 900 mg (23% yield) of the desired compound were obtained.

Sources & evidence

ORD record
ord-874ecdfba87d469e8905c35adf65af68
Source dataset
uspto-grants-2016_05
Patent number
US09340547B2

Reaction notes

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