Hydrochloric Acid → HCID 178479268, compound

HRID 525267Notes

Reaction equation

HRID 525267 reaction equation
[ClH:1].[N:2]1[CH:7]=[CH:6][CH:5]=[N:4][C:3]=1[NH:8][C@@H:9]1[CH2:14][CH2:13][C@H:12]([NH:15]C(=O)OC(C)(C)C)[CH2:11][CH2:10]1>>[ClH:1].[N:2]1[CH:7]=[CH:6][CH:5]=[N:4][C:3]=1[NH:8][C@H:9]1[CH2:14][CH2:13][C@@H:12]([NH2:15])[CH2:11][CH2:10]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 178454024HCID 178454024, compound

Product 1

HCID 178479268HCID 178479268, compound

Procedure

As shown in step 5-ii of Scheme 5, HCl (3 mL, 4M in THF, 12 mmol) was added to compound 1010. The mixture was stirred for 30 min and concentrated under reduced pressure to produce (cis)-N1-(pyrimidin-2-yl)cyclohexane-1,4-diamine hydrochloride (compound 1011). This material was used in subsequent reactions as is without further purification.

Workup

  1. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-406b7b5944e845a487ba3cb58c5c9a53
Source dataset
uspto-grants-2016_05
Patent number
US09340557B2

Reaction notes

Loading…