3-(Diethylboryl)pyridine → Abiraterone Acetate

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	3-(Diethylboryl)pyridine	HCID 642851	—
Edukt	((3S,8R,9S,10R,13S,14S)-10,13-dimethyl-17-(trifluoromethylsulfonyloxy)-2,3,4,7,8,9,11,12,14,15-decahydro-1H-cyclopenta(a)phenanthren-3-yl) acetate	HCID 10457059	—
Produkt	Abiraterone Acetate	HCID 9821849	—

Reaktionsschritte

The Suzuki reaction between 3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate (II) and diethyl(3-pyridyl)borane affords crude abiraterone acetate which is purified by silica gel chromatography, eluting with a mixture of ethyl ether and petroleum ether, and finally crystallised from hexane.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US09340571B2
Quelldatensatz	uspto-grants-2016_05
ORD ID	ord-6bad42bc2af8438bbf7cc845c0ea09b4
Quellennotiz	uspto-grants-2016_05