反应详情

To a flask charged with 1-(1,4-dioxaspiro[4.5]decan-8-yl)-1H-benzo[d]imidazol-2(3H)-one (1.100 g, 4.01 mmol) were added acetone (7.29 mL) and water (0.729 mL) followed by PPTS (1.310 g, 5.21 mmol). The resulting light brown solution was heated at reflux overnight. Water was then added to the mixture leading to an oiling out of the organics. The mixture was transferred to a separatory funnel and extracted with EtOAc (2×). The combined organic layers were dried with Na2SO4, filtered, and dried under reduced pressure. The oil thus obtained was purified with a 50 g SNAP column (Biotage) ramping DCM:MeOH:NH4OH (90:10:1) in DCM from 0-35% leading to coelution of product and starting material. The mixture was used in the next step without further purification. The mixture containing 1-(4-oxocyclohexyl)-1H-benzo[d]imidazol-2(3H)-one (0.685 g, 2.97 mmol, 74.2% yield) was obtained as a brown foam. m/z (ESI) 231.2 (M+H)+.

1. temperatureThe resulting light brown solution was heated
2. temperatureat reflux overnight
3. customThe mixture was transferred to a separatory funnel
4. extractionextracted with EtOAc (2×)
5. dry with materialThe combined organic layers were dried with Na2SO4
6. filtrationfiltered
7. customdried under reduced pressure
8. customThe oil thus obtained
9. customwas purified with a 50 g SNAP column (Biotage)
10. customThe mixture was used in the next step without further purification