HCID 68279452, compound → HCID 57516952, compound

HRID 525424Notes

Reaction equation

HRID 525424 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[C:8]([CH2:13][OH:14])[N:7]=[CH:6]2>CC(=O)OCC>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[C:8]([CH:13]=[O:14])[N:7]=[CH:6]2

Participants

3

Reactant 1

HCID 68279452HCID 68279452, compound

Product 1

HCID 57516952HCID 57516952, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Conditions

Temperature
80 °C

Procedure

To the solution of (6-methoxyquinazolin-2-yl)methanol (4 g, 0.21 mol) in EA (30 mL) was added IBX (11.6 g, 4.2 mol, 2 eq). The reaction was stirred at 80° C. for 16 h. After filtration, the solution was evaporated in vacuum to give 6-methoxyquinazoline-2-carbaldehyde (3.8 g, yield: 95%) as a white solid. ESI-MS: m/z 189.2 ([M+1]+).

Workup

  1. filtrationAfter filtration
  2. customthe solution was evaporated in vacuum

Sources & evidence

ORD record
ord-ddfbcd360f9f4793b1b04a6d417733fe
Source dataset
uspto-grants-2016_05
Patent number
US09340527B2

Reaction notes

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