HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Azepane-4-carboxylic acid hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | 1-[(Tert-butoxy)carbonyl]azepane-4-carboxylic acid | HCID 23160608 | — |
| Product | Azepane-4-carboxylic acid hydrochloride | HCID 68279383 | — |
Reaction Steps
Perhydro-azepine-1,4-dicarboxylic acid 1-tert-butyl ester (1 g, 4 mmol) was dissolved in 4 M of Hydrogen chloride in 1,4-Dioxane (10 mL, 40 mmol) and stirred at room temperature for 1 hour. Crude reaction was concentrated to dryness and used without additional purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09340527B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-11beef46e3d64614a74589430f60af17 |
| Source note | uspto-grants-2016_05 |