Hydrochloric Acid → Azepane-4-carboxylic acid hydrochloride

HRID 525456Notes

Reaction equation

HRID 525456 reaction equation
C(OC([N:8]1[CH2:14][CH2:13][CH2:12][CH:11]([C:15]([OH:17])=[O:16])[CH2:10][CH2:9]1)=O)(C)(C)C.O1CCOCC1.[ClH:24]>>[ClH:24].[NH:8]1[CH2:14][CH2:13][CH2:12][CH:11]([C:15]([OH:17])=[O:16])[CH2:10][CH2:9]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 231606081-[(Tert-butoxy)carbonyl]azepane-4-carboxylic acid

Product 1

HCID 68279383Azepane-4-carboxylic acid hydrochloride

Procedure

Perhydro-azepine-1,4-dicarboxylic acid 1-tert-butyl ester (1 g, 4 mmol) was dissolved in 4 M of Hydrogen chloride in 1,4-Dioxane (10 mL, 40 mmol) and stirred at room temperature for 1 hour. Crude reaction was concentrated to dryness and used without additional purification.

Workup

  1. customCrude reaction
  2. concentrationwas concentrated to dryness
  3. customused without additional purification

Sources & evidence

ORD record
ord-11beef46e3d64614a74589430f60af17
Source dataset
uspto-grants-2016_05
Patent number
US09340527B2

Reaction notes

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