HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 525670Generated: October 30, 2026
2-(Ethylamino)ethanol → 5-bromo-6-(ethyl(2-hydroxyethyl)amino)-N-(4-(trifluoromethoxy)phenyl)nicotinamide
https://huagongshe.com/reaction/525670
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-(Ethylamino)ethanol | HCID 8072 | — |
| Reactant | 5-bromo-6-chloro-N-(4-(trifluoromethoxy)phenyl)nicotinamide | HCID 86702595 | — |
| Product | 5-bromo-6-(ethyl(2-hydroxyethyl)amino)-N-(4-(trifluoromethoxy)phenyl)nicotinamide | HCID 89906577 | — |
Reaction Steps
The title compound was prepared in an analogous fashion to that described in Stage 22.1 using 5-bromo-6-chloro-N-(4-(trifluoromethoxy)phenyl)nicotinamide (Stage 6.2) and 2-(ethylamino)ethanol to afford a white solid. (The RM was heated at 140° C. for 18 h). HPLC (Condition 4) tR=5.92 min, UPLC-MS (Condition 3) tR=1.19 min, m/z=450.1 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09340537B2 |
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| Source dataset | uspto-grants-2016_05 |
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| ORD ID | ord-cf8f939c4493439cbd30d5cf4585539d |
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| Source note | uspto-grants-2016_05 |
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