反应详情

TFA (7.3 mL) was added to a solution of 6-chloro-N-(4-(chlorodifluoromethoxy)phenyl)-5-(1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-5-yl)nicotinamide (Stage 48.2, 1.285 g, 2.366 mmol) in DCM (20 mL) and the RM was stirred at RT. The solvent was evaporated off under reduced pressure and the residue was dissolved in EtOAc (150 mL), washed with aq. sat. NaHCO3 solution (2×50 mL) and water (2×50 mL) dried over Na2SO4 and the solvent was evaporated off under reduced pressure to give a residue was crystallized from iPr2O/EtOAc to give the title product as a white solid. HPLC (Condition 7) tR=6.797 min, UPLC-MS (Condition 3) tR=1.05-min, m/z=398.9/401.0 [M+H]+.

1. customThe solvent was evaporated off under reduced pressure
2. dissolutionthe residue was dissolved in EtOAc (150 mL)
3. washwashed with aq. sat. NaHCO3 solution (2×50 mL) and water (2×50 mL)
4. dry with materialdried over Na2SO4
5. customthe solvent was evaporated off under reduced pressure
6. customto give a residue
7. customwas crystallized from iPr2O/EtOAc