HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → trans-3-Amino-4-methoxypyrrolidine dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Ethanol | HCID 702 | — |
| Reactant | rac-tert-butyl (3R,4R)-3-amino-4-methoxypyrrolidine-1-carboxylate hydrochloride | HCID 89906581 | — |
| Product | trans-3-Amino-4-methoxypyrrolidine dihydrochloride | HCID 67925434 | — |
Reaction Steps
A mixture of (trans)-tert-butyl 3-amino-4-methoxypyrrolidine-1-carboxylate hydrochloride (0.5 g, 1.939 mmol) and HCl in EtOH (15.51 mL, 19.39 mmol) was stirred at RT for 24 h. The solvent was evaporated off under reduced pressure to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09340537B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-84f24c5cc7c54af8a3e6cfe8c58b6d4e |
| Source note | uspto-grants-2016_05 |