Hydrochloric Acid → trans-3-Amino-4-methoxypyrrolidine dihydrochloride

HRID 525757Notes

Reaction equation

[ClH:1].[NH2:2][C@H:3]1[C@H:7]([O:8][CH3:9])[CH2:6][N:5](C(OC(C)(C)C)=O)[CH2:4]1.Cl.CCO>>[ClH:1].[ClH:1].[CH3:9][O:8][C@@H:7]1[CH2:6][NH:5][CH2:4][C@H:3]1[NH2:2]

Participants

Reactant 3

HCID 313Hydrochloric Acid

HCID 702Ethanol

HCID 89906581rac-tert-butyl (3R,4R)-3-amino-4-methoxypyrrolidine-1-carboxylate hydrochloride

Product 1

HCID 67925434trans-3-Amino-4-methoxypyrrolidine dihydrochloride

Procedure

A mixture of (trans)-tert-butyl 3-amino-4-methoxypyrrolidine-1-carboxylate hydrochloride (0.5 g, 1.939 mmol) and HCl in EtOH (15.51 mL, 19.39 mmol) was stirred at RT for 24 h. The solvent was evaporated off under reduced pressure to give the title compound.

Workup

customThe solvent was evaporated off under reduced pressure

Sources & evidence

ORD record: ord-84f24c5cc7c54af8a3e6cfe8c58b6d4e
Source dataset: uspto-grants-2016_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09340537B2

Reaction notes

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