Trifluoroacetic acid → HCID 136381092, compound

HRID 52578Notes

Reaction equation

HRID 52578 reaction equation
[NH2:1][C:2](=[N:29][N+:30]([O-:32])=[O:31])[NH:3][CH2:4][CH2:5][CH2:6][C@H:7]([C:16]([NH:18][CH2:19][C:20]1[CH:25]=[CH:24][C:23]([C:26](=[O:28])[CH3:27])=[CH:22][CH:21]=1)=[O:17])[NH:8]C(OC(C)(C)C)=O.FC(F)(F)C(O)=O>ClCCl.O>[NH2:1][C:2](=[N:29][N+:30]([O-:32])=[O:31])[NH:3][CH2:4][CH2:5][CH2:6][C@H:7]([C:16]([NH:18][CH2:19][C:20]1[CH:21]=[CH:22][C:23]([C:26](=[O:28])[CH3:27])=[CH:24][CH:25]=1)=[O:17])[NH2:8]

Participants

5

Reactant 2

HCID 6422Trifluoroacetic acidHCID 136381093HCID 136381093, compound

Product 1

HCID 136381092HCID 136381092, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6344DichloromethaneSolvent

Procedure

Prepared analogously to Example 5e) from (R)-N5 -[amino(nitroimino)methyl]-N2 -(tert.-butoxycarbonyl)-N-[[4-(1-oxoethyl)-phenyl]methyl]-ornithinamide by treating with trifluoroacetic acid in dichloromethane. The salt thus obtained was dissolved in water, this solution was made ammoniacal and the desired base was finally precipitated from the aqueous solution by saturating with common salt. The product obtained was dried in vacuo in diphosphorus pentoxide and used in the following stage without any further purification.

Workup

  1. customThe salt thus obtained
  2. customthe desired base was finally precipitated from the aqueous solution
  3. concentrationby saturating with common salt
  4. customThe product obtained
  5. dry with materialwas dried in vacuo in diphosphorus pentoxide
  6. customused in the following stage without any further purification

Sources & evidence

ORD record
ord-3769858963464367ad96664b8e96aaa0
Source dataset
uspto-grants-1997_04
Patent number
US05616620

Reaction notes

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