Benzenepropanol, .alpha.-ethyl-.alpha.-methyl- → HCID 86722208, compound

HRID 525784Notes

Reaction equation

HRID 525784 reaction equation
[CH3:1][C:2]([OH:13])([CH2:11][CH3:12])[CH2:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1>O1CCCC1.[Ru]>[CH:5]1([CH2:4][CH2:3][C:2]([CH3:1])([OH:13])[CH2:11][CH3:12])[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6]1

Participants

4

Reactant 1

HCID 61516Benzenepropanol, .alpha.-ethyl-.alpha.-methyl-

Product 1

HCID 86722208HCID 86722208, compound

Reagents, catalysts & solvents 2

HCID 23950RutheniumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

A 300 ml autoclave was initially charged with 5.6 g of 3-methyl-1-phenyl-3-pentanol, dissolved in 94.4 g of tetrahydrofuran, and 1.6 g of a catalyst prepared according to Example 1 (0.35% ruthenium on silicon dioxide). The autoclave was flushed three times with nitrogen and then hydrogenated for 10 hours at 160° C. and a hydrogen pressure of 160 bar. The product was analyzed by gas chromatography (polydimethylsiloxane DB1, 30 m, internal diameter: 0.25 mm, film thickness: 0.25 μm, 50° C., 5 min isotherm, −6° C./min, 290° C., 219 min isotherm). The conversion was 99.9%, the selectivity 93%.

Workup

  1. customThe autoclave was flushed three times with nitrogen
  2. customwas analyzed by gas chromatography (polydimethylsiloxane DB1, 30 m, internal diameter: 0.25 mm, film thickness: 0.25 μm, 50° C., 5 min isotherm, −6° C./min, 290° C., 219 min isotherm)

Sources & evidence

ORD record
ord-a79455c519c34529befe1e182c61c1f7
Source dataset
uspto-grants-2016_05
Patent number
US09340754B2

Reaction notes

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