反应详情

To a solution of (6R,7R)-benzhydryl 7-((Z)-2-(((1-(tert-butoxy)-2-methyl-1-oxopropan-2-yl)oxy)imino)-2-(2-((tert-butoxycarbonyl)amino)thiazol-4-yl)acetamido)-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate 5-oxide (2.68 g, 3.18 mmol) in acetone (40 mL) was added sodium iodide (0.715 g, 4.77 mmol). The mixture was stirred at room temperature over 3 h. LCMS indicated completion of the reaction. The solid was filtered off, the filtrate was concentrated under vacuum to afford (6R,7R)-benzhydryl 7-((Z)-2-(((1-(tert-butoxy)-2-methyl-1-oxopropan-2-yl)oxy)imino)-2-(2-((tert-butoxycarbonyl)amino)thiazol-4-yl)acetamido)-3-(iodomethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate 5-oxide (2.97 g, 3.18 mmol, 100% yield) as a dark red solid. LCMS: (M+H)+: 934.0.

1. customcompletion of the reaction
2. filtrationThe solid was filtered off
3. concentrationthe filtrate was concentrated under vacuum