HRID52588

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID176

Acetic Acid

C2H4O2

结构：NC(=N[N+](=O)[O-])NCCC[C@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc2[nH]ccc2c1

HCID136381104

未命名化合物

PRODUCTS

生成物

结构：CC(=O)[O-].N#N.N=C(N)NCCC[C@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc2[nH]ccc2c1

HCID178476730

未命名化合物

收率 54%

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID23938

Palladium

PROCEDURE

实验过程

Prepared analogously to Example 1c) from N5 -[amino(nitroimino)methyl]-N2 -(diphenylacetyl)-N-[(1H-indol-5-yl)methyl]-ornithinamide by catalytic hydrogenation in the presence of palladium black and 80% aqueous acetic acid in a yield of 54% of theory.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-bc7c2b265dab44cf8d65451939da42e6
来源数据集: uspto-grants-1997_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05616620
来源说明: uspto-grants-1997_04

反应 SMILES

[NH2:1][C:2](=[N:37][N+:38]([O-])=O)[NH:3][CH2:4][CH2:5][CH2:6][C@@H:7]([C:24]([NH:26][CH2:27][C:28]1[CH:29]=[C:30]2[C:34](=[CH:35][CH:36]=1)[NH:33][CH:32]=[CH:31]2)=[O:25])[NH:8][C:9](=[O:23])[CH:10]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.[C:41]([OH:44])(=[O:43])[CH3:42]>[Pd]>[N:37]#[N:38].[C:17]1([CH:10]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:9]([NH:8][C@H:7]([C:24]([NH:26][CH2:27][C:28]2[CH:29]=[C:30]3[C:34](=[CH:35][CH:36]=2)[NH:33][CH:32]=[CH:31]3)=[O:25])[CH2:6][CH2:5][CH2:4][NH:3][C:2](=[NH:1])[NH2:37])=[O:23])[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1.[C:41]([O-:44])(=[O:43])[CH3:42]