Hydrochloric Acid → (R)-N-[(4-Amino-3,5-dibromophenyl)methyl]-N5-[amino(nitroimino)methyl]-ornithinamide-hydrochloride

HRID 52589Notes

Reaction equation

[NH2:1][C:2]1[C:7]([Br:8])=[CH:6][C:5]([CH2:9][NH:10][C:11](=[O:31])[C@@H:12]([CH2:21][CH2:22][CH2:23][NH:24][C:25]([NH2:30])=[N:26][N+:27]([O-:29])=[O:28])[NH:13]C(OC(C)(C)C)=O)=[CH:4][C:3]=1[Br:32].[ClH:33]>>[ClH:33].[NH2:1][C:2]1[C:3]([Br:32])=[CH:4][C:5]([CH2:9][NH:10][C:11](=[O:31])[C@@H:12]([CH2:21][CH2:22][CH2:23][NH:24][C:25]([NH2:30])=[N:26][N+:27]([O-:29])=[O:28])[NH2:13])=[CH:6][C:7]=1[Br:8]

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 136381107(R)-N-[(4-amino-3,5-dibromophenyl)methyl]-N5-[amino(nitroimino)methyl]-N2-[(tert.-butyloxy)carbonyl]-ornithinamide

Product 1

HCID 136381105(R)-N-[(4-Amino-3,5-dibromophenyl)methyl]-N5-[amino(nitroimino)methyl]-ornithinamide-hydrochloride

Procedure

Prepared analogously to Example 36b) from (R)-N-[(4-amino-3,5-dibromophenyl)methyl]-N5 -[amino(nitroimino)methyl]-N2 -[(tert.-butyloxy)carbonyl]-ornithinamide by treating with methanolic hydrochloric acid in a quantitative yield.

Sources & evidence

ORD record: ord-6d677ec2b72145d791b9f514477f819b
Source dataset: uspto-grants-1997_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05616620

Reaction notes

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