HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → (R)-N5-[Amino(nitroimino)methyl]-N-[(2-thienyl)methyl]-ornithinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | (2-Thienylmethyl)amine | HCID 34005 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | (R)-N5-[amino(nitroimino)methyl]-N2-[(tert.-butyloxy)carbonyl]-N-[(2-thienyl)methyl]-ornithinamide | HCID 136381109 | — |
| Reactant | HCID 178454200 | HCID 178454200 | — |
| Product | (R)-N5-[Amino(nitroimino)methyl]-N-[(2-thienyl)methyl]-ornithinamide | HCID 136381108 | — |
Reaction Steps
First of all Boc-Arg(NO2)-OH was reacted with thiophene-2-methanamine and TBTU as in Example 8a). The resulting (R)-N5 -[amino(nitroimino)methyl]-N2 -[(tert.-butyloxy)carbonyl]-N-[(2-thienyl)methyl]-ornithinamide was then reacted, without purification, with trifluoroacetic acid as in Example 23b). The crude product obtained in a quantitative yield was further processed without purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05616620 |
| Source dataset | uspto-grants-1997_04 |
| ORD ID | ord-1c1598767bea497387d3419ad8b568de |
| Source note | uspto-grants-1997_04 |