反应详情

To a suspension of 1-ethyl-5-nitro-4-oxo-1,4-dihydro-[1,3]dioxolo[4,5-g]cinnoline-3-carboxylic acid (4.25 g, 13.83 mmol) in Acetic Acid (100 mL) and hydrochloric acid (30 mL) in parr shaker bottle was added Pd/C (0.6 g, 5.64 mmol) and the mixture was hydrogenated at 50 psi on a parr shaker for 5 h. The mixture was filtered. The filtrate was allowed to drop into 500 ml of water and the precipitate was collected by filtration, dried to afford 5-amino-1-ethyl-4-oxo-1,4-dihydro-[1,3]dioxolo[4,5-g]cinnoline-3-carboxylic acid (3.6 g, 12.99 mmol, 94% yield). LCMS: (M+H)+: 278.2

1. filtrationThe mixture was filtered
2. filtrationthe precipitate was collected by filtration
3. customdried