Trifluoroacetic acid → HCID 136381114, compound

HRID 52597Notes

Reaction equation

[NH2:1][C:2](=[N:32][N+:33]([O-:35])=[O:34])[NH:3][CH2:4][CH2:5][CH2:6][C@H:7]([C:16]([NH:18][CH:19]([C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)=[O:17])[NH:8]C(OC(C)(C)C)=O.[F:36][C:37]([F:42])([F:41])[C:38]([OH:40])=[O:39]>>[NH2:1][C:2](=[N:32][N+:33]([O-:35])=[O:34])[NH:3][CH2:4][CH2:5][CH2:6][C@H:7]([C:16]([NH:18][CH:19]([C:26]1[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=1)[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)=[O:17])[NH2:8].[F:36][C:37]([F:42])([F:41])[C:38]([O-:40])=[O:39]

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 136381116HCID 136381116, compound

Product 1

HCID 136381114HCID 136381114, compoundYield 95%

Procedure

Prepared analogously to Example 5e) from (R)-N5 -[amino(nitroimino)methyl]-N2 -[(tert.-butyloxy)carbonyl]-N-(diphenylmethyl)-ornithinamide by the action of trifluoroacetic acid in a yield of 95% of theory.

Sources & evidence

ORD record: ord-4c29322d77f143ae9d6efafa595ad860
Source dataset: uspto-grants-1997_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05616620

Reaction notes

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