Methylamine → HCID 86732841, compound

HRID 525974Notes

Reaction equation

[Cl:1][C:2]1[C:11]([O:12][CH2:13][C:14]2[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=2)=[C:10]([O:22][CH2:23][C:24]2[CH:29]=[CH:28][C:27]([O:30][CH3:31])=[CH:26][CH:25]=2)[CH:9]=[C:8]2[C:3]=1[C:4](=[O:41])[C:5]([CH2:35][N:36]1[CH2:40][CH2:39][CH2:38][CH2:37]1)=[CH:6][N:7]2[CH:32]1CC1.CN>>[Cl:1][C:2]1[C:11]([O:12][CH2:13][C:14]2[CH:15]=[CH:16][C:17]([O:20][CH3:21])=[CH:18][CH:19]=2)=[C:10]([O:22][CH2:23][C:24]2[CH:29]=[CH:28][C:27]([O:30][CH3:31])=[CH:26][CH:25]=2)[CH:9]=[C:8]2[C:3]=1[C:4](=[O:41])[C:5]([CH2:35][N:36]1[CH2:40][CH2:39][CH2:38][CH2:37]1)=[CH:6][N:7]2[CH3:32]

Participants

Reactant 2

HCID 6329Methylamine

HCID 86732842HCID 86732842, compound

Product 1

HCID 86732841HCID 86732841, compound

Procedure

This compound was prepared according to the procedures for the preparation of 5-chloro-1-cyclopropyl-6,7-bis((4-methoxybenzyl)oxy)-3-(pyrrolidin-1-ylmethyl)quinolin-4(1H)-one as described in Examples 50a-50b and 54a-54g, utilizing methanamine in place of cyclopropanamine in Example 50a. LCMS: (M+H)+: 549.3.

Workup

customThis compound was prepared

Sources & evidence

ORD record: ord-b6509e3053cd473db029d75e821d140a
Source dataset: uspto-grants-2016_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09340556B2

Reaction notes

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