1-(4,6-Dichloro-1,5-naphthyridin-3-yl)ethan-1-one → HCID 178467144, compound

HRID 526178Notes

Reaction equation

HRID 526178 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([Cl:12])[N:10]=2)[N:5]=[CH:4][C:3]=1[C:13](=[O:15])[CH3:14].[CH3:16][N:17]([CH2:19][C@@H:20]1[CH2:25][CH2:24][C@H:23]([NH2:26])[CH2:22][CH2:21]1)[CH3:18]>>[Cl:12][C:9]1[N:10]=[C:11]2[C:6](=[CH:7][CH:8]=1)[N:5]=[CH:4][C:3]([C:13](=[O:15])[CH3:14])=[C:2]2[NH:26][C@H:23]1[CH2:24][CH2:25][C@@H:20]([CH2:19][N:17]([CH3:18])[CH3:16])[CH2:21][CH2:22]1

Participants

3

Reactant 2

HCID 897049771-(4,6-Dichloro-1,5-naphthyridin-3-yl)ethan-1-oneHCID 178483673HCID 178483673, compound

Product 1

HCID 178467144HCID 178467144, compoundYield 55.4%

Procedure

Following general procedure I, 1-(4,6-dichloro-1,5-naphthyridin-3-yl)ethanone (500 mg, 2.1 mmol) was reacted with cis-4-[(dimethylamino)methyl]cyclohexanamine (300 mg, 2.0 mmol) to afford the desired product (400 mg, 55%) as a yellow solid: ESI MS m/z 361 [M+H]+;

Sources & evidence

ORD record
ord-847fef2664794575927a90db8a6632a8
Source dataset
uspto-grants-2016_05
Patent number
US09345709B2

Reaction notes

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