Hydrochloric Acid → HCID 117774125, compound

HRID 526211Notes

Reaction equation

HRID 526211 reaction equation
[C:1]([C:4]1[CH:5]=[N:6][C:7]2[C:12]([C:13]=1[NH:14][C@H:15]1[CH2:20][CH2:19][C@H:18]([NH:21]C(=O)OC(C)(C)C)[CH2:17][CH2:16]1)=[N:11][C:10]([Cl:29])=[CH:9][CH:8]=2)(=[O:3])[CH3:2].[ClH:30]>>[ClH:29].[ClH:30].[NH2:21][CH:18]1[CH2:19][CH2:20][CH:15]([NH:14][C:13]2[C:12]3[C:7](=[CH:8][CH:9]=[C:10]([Cl:29])[N:11]=3)[N:6]=[CH:5][C:4]=2[C:1](=[O:3])[CH3:2])[CH2:16][CH2:17]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 178467150HCID 178467150, compound

Product 1

HCID 117774125HCID 117774125, compoundYield 56%

Procedure

Following general procedure IV-1, tert-butyl {trans-4-[(3-acetyl-6-chloro-1,5-naphthyridin-4-yl)amino]cyclohexyl}carbamate (360 mg, 0.86 mmol) was reacted with HCl (5 mL, 2 M in ether) to afford the desired product (190 mg, 56%) as a white solid. ESI MS m/z 318 [M+H]+

Sources & evidence

ORD record
ord-c0e99f120f3840cc95b94ff86aac492b
Source dataset
uspto-grants-2016_05
Patent number
US09345709B2

Reaction notes

Loading…