2,4-Diamino-5-chloro-6-nitroquinazoline → 2,4,6-Triamino-5-chloroquinazoline

HRID 52638Notes

Reaction equation

HRID 52638 reaction equation
[NH2:1][C:2]1[N:11]=[C:10]([NH2:12])[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([N+:14]([O-])=O)[C:8]=2[Cl:13])[N:3]=1>[Pt].COCCO.C(O)C>[NH2:1][C:2]1[N:11]=[C:10]([NH2:12])[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([NH2:14])[C:8]=2[Cl:13])[N:3]=1

Participants

5

Reactant 1

HCID 125168262,4-Diamino-5-chloro-6-nitroquinazoline

Product 1

HCID 1522172,4,6-Triamino-5-chloroquinazoline

Reagents, catalysts & solvents 3

HCID 23939PlatinumCatalystHCID 702EthanolSolventHCID 80192-MethoxyethanolSolvent

Procedure

This compound was prepared in a manner analogous to that of Example 13, using 11.0 grams (0.049 mole) of 2,4-diamino-5-chloro-6-nitroquinazoline and 1.0 gram of 10% platinum on carbon in 70 mL of 2-methoxyethanol and 130 mL of ethanol, yielding 2,4,6-triamino-5-chloroquinazoline.

Workup

  1. customThis compound was prepared in a manner analogous to that of Example 13

Sources & evidence

ORD record
ord-f6ef60545a874d35955b5ceca43f69ef
Source dataset
uspto-grants-1997_04
Patent number
US05616718

Reaction notes

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