Dichloromethane → Hydrochloric Acid
Reaction equation
[F:1][C:2]1([F:17])[CH2:8][N:7](C(OC(C)(C)C)=O)[CH2:6][CH2:5][N:4]([CH3:16])[CH2:3]1.O1CCOCC1.[Cl:24]CCl>Cl>[F:1][C:2]1([F:17])[CH2:3][N:4]([CH3:16])[CH2:5][CH2:6][NH:7][CH2:8]1.[ClH:24]Participants
6
Reactant 3
Product 2
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 20 °C
Procedure
Combined a solution of tert-butyl 6,6-difluoro-4-methyl-1,4-diazepane-1-carboxylate (50 mg, 0.200 mmol) in dichloromethane (2 mL) and 4 M HCl in dioxane (0.4 mL, 1.6 mmol) and the solution stirred at 20° C. for 21 h. The reaction was then concentrated in vacuo to give the title compound as a hydrochloride acid salt which was used without further purification. MS: 151 (M+H).
Workup
- concentrationThe reaction was then concentrated in vacuo
Sources & evidence
- ORD record
- ord-9ea8db006b7b458891417498f8da859e
- Source dataset
- uspto-grants-2016_05
- Patent number
- US09345713B2
Reaction notes
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