HCID 117666006, compound → HCID 178458270, compound

HRID 526752Notes

Reaction equation

HRID 526752 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:12]2[C:16]([CH:17]=[O:18])=[CH:15][N:14](C3CCCCO3)[N:13]=2)[CH:5]=[CH:6][C:7]=1[O:8][CH:9]([CH3:11])[CH3:10]>Cl>[Cl:1][C:2]1[CH:3]=[C:4]([C:12]2[C:16]([CH:17]=[O:18])=[CH:15][NH:14][N:13]=2)[CH:5]=[CH:6][C:7]=1[O:8][CH:9]([CH3:11])[CH3:10]

Participants

3

Reactant 1

HCID 117666006HCID 117666006, compound

Product 1

HCID 178458270HCID 178458270, compoundYield 116.4%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Conditions

Temperature
25 °C

Procedure

A mixture of 3-(3-chloro-4-isopropoxyphenyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole-4-carbaldehyde (600 mg, 1.72 mmol, 1.00 equiv) in a saturated methanolic HCl (50 mL) was stirred at 25° C. for 2 h. The resulting mixture was concentrated under vacuum to give 530 mg of crude 3-(3-chloro-4-isopropoxyphenyl)-1H-pyrazole-4-carbaldehyde as a white solid. LCMS (method C, ESI): RT=0.86 min, m/z=265.0 [M+H]+.

Workup

  1. concentrationThe resulting mixture was concentrated under vacuum

Sources & evidence

ORD record
ord-a2e873cd521347a58d7dfdd007613748
Source dataset
uspto-grants-2016_05
Patent number
US09346761B2

Reaction notes

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