(R)-Tetrahydro-3-furoic acid → HCID 68007695, compound

HRID 526910Notes

Reaction equation

HRID 526910 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:10]([C:11]3[N:16]=[C:15]([NH:17][C@H:18]4[CH2:22][CH2:21][N:20](S(C)(=O)=O)[CH2:19]4)[C:14]([F:27])=[CH:13][N:12]=3)=[CH:9][NH:8][C:5]2=[N:6][CH:7]=1.[O:28]1[CH2:32][CH2:31][CH:30]([C:33](O)=[O:34])[CH2:29]1>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:10]([C:11]3[N:16]=[C:15]([NH:17][C@H:18]4[CH2:22][CH2:21][N:20]([C:33]([CH:30]5[CH2:31][CH2:32][O:28][CH2:29]5)=[O:34])[CH2:19]4)[C:14]([F:27])=[CH:13][N:12]=3)=[CH:9][NH:8][C:5]2=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 4661317(R)-Tetrahydro-3-furoic acidHCID 68008525(S)-2-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoro-N-(1-(methylsulfonyl)pyrrolidin-3-yl)pyrimidin-4-amine

Product 1

HCID 68007695HCID 68007695, compoundYield 52%

Procedure

According to the procedure for compound 398 using tetrahydrofuran-3-carboxylic acid (35 mg, 0.30 mmol) afforded 22.2 mg (52% yield) of 478, as a solid.

Sources & evidence

ORD record
ord-65e4456bbb624d00b91e42ef4f08d4c9
Source dataset
uspto-grants-2016_05
Patent number
US09345708B2

Reaction notes

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