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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 526910Generated: November 1, 2026

(R)-Tetrahydro-3-furoic acid → HCID 68007695, compound

https://huagongshe.com/reaction/526910

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(R)-Tetrahydro-3-furoic acidHCID 4661317—
Reactant(S)-2-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoro-N-(1-(methylsulfonyl)pyrrolidin-3-yl)pyrimidin-4-amineHCID 68008525—
ProductHCID 68007695HCID 6800769552%

Reaction Steps

According to the procedure for compound 398 using tetrahydrofuran-3-carboxylic acid (35 mg, 0.30 mmol) afforded 22.2 mg (52% yield) of 478, as a solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09345708B2
Source datasetuspto-grants-2016_05
ORD IDord-65e4456bbb624d00b91e42ef4f08d4c9
Source noteuspto-grants-2016_05