HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloride → HCID 68008112, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloride | HCID 312 | — |
| Reactant | HCID 68007303 | HCID 68007303 | — |
| Reactant | N-((trans-2-aminocyclohexyl)methyl)-2-(5-chloro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-amine | HCID 68007392 | — |
| Product | HCID 68008112 | HCID 68008112 | — |
Reaction Steps
Urea 564 was prepared according to the procedure for compound 20 (Scheme 12A) using N-((trans-2-aminocyclohexyl)methyl)-2-(5-chloro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-amine, 14f, and dimethylcarbomoyl chloride, afforded desired product, 564, as a racemic mixture of trans isomers.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09345708B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-9e6c1fe8da6b4ea0a2170dd1e0c72328 |
| Source note | uspto-grants-2016_05 |