huagongshe.com
HRID526941

反应详情

EQUATION

反应方程式

HRID 526941 的结构方程式

REACTANTS

反应物

3
结构：[Cl-]
HCID312

Chloride

Cl-

结构：CC(C)(C)NC(=O)N1CCC[C@@H](CNc2nc(-c3c[nH]c4ncc(Cl)cc34)ncc2F)C1
HCID68007303

未命名化合物

结构：Cc1ccc(S(=O)(=O)n2cc(-c3ncc(F)c(NC[C@@H]4CCCC[C@H]4N)n3)c3cc(Cl)cnc32)cc1
HCID68007392

未命名化合物

PRODUCTS

生成物

1
结构：CN(C)C(=O)N[C@@H]1CCCC[C@H]1CNc1nc(-c2c[nH]c3ncc(Cl)cc23)ncc1F
HCID68008112

未命名化合物

PROCEDURE

实验过程

Urea 564 was prepared according to the procedure for compound 20 (Scheme 12A) using N-((trans-2-aminocyclohexyl)methyl)-2-(5-chloro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-amine, 14f, and dimethylcarbomoyl chloride, afforded desired product, 564, as a racemic mixture of trans isomers.

WORKUP

后处理

  1. customUrea 564 was prepared