Hydrochloric Acid → HCID 68008586, compound

HRID 527000Notes

Reaction equation

HRID 527000 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:10]([C:11]3[N:16]=[C:15]([NH:17][C@H:18]4[CH2:23][CH2:22][CH2:21][C@@H:20]([NH:24][CH2:25][CH2:26][N:27](C)[C:28](=O)OC(C)(C)C)[CH2:19]4)[C:14]([F:36])=[CH:13][N:12]=3)=[CH:9][NH:8][C:5]2=[N:6][CH:7]=1.Cl.O1CCOCC1>ClCCl.CO>[Cl:1][C:2]1[CH:3]=[C:4]2[C:10]([C:11]3[N:16]=[C:15]([NH:17][C@H:18]4[CH2:23][CH2:22][CH2:21][C@@H:20]([NH:24][CH2:25][CH2:26][NH:27][CH3:28])[CH2:19]4)[C:14]([F:36])=[CH:13][N:12]=3)=[CH:9][NH:8][C:5]2=[N:6][CH:7]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 68007635HCID 68007635, compound2×

Product 1

HCID 68008586HCID 68008586, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

In a flask containing tert-butyl 2-((1R,3S)-3-(2-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-ylamino)cyclohexylamino)ethyl(methyl)carbamate, 47b, (0.02 g, 0.04 mmol) in dichloromethane/MeOH mixture was added HCl in Dioxane (3.86 mL of 4 M solution, 15.44 mmol). The solution was stirred at room temperature for 12 hrs. The solvent was evaporated under reduced pressure and used without further purification.

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. customused without further purification

Sources & evidence

ORD record
ord-bc2edfc35bf94d269045fc1b6d1882e8
Source dataset
uspto-grants-2016_05
Patent number
US09345708B2

Reaction notes

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