反应详情

N-(3,4-dimethylphenyl)acetamide (915 mg, 5.62 mmol) and ninhydrin (1.00 g, 5.62 mmol) were dissolved in conc. sulfuric acid (20 mL) and stirred at room temperature for 1.5 hrs. The reaction was stopped by slowing pouring the solution to 150 g of ice and stirring. The reaction mixture was extracted with ethylacetate and water, washed with brine. The washed organic layer was dried over sodium sulfate, concentrated in a vacuum, and purified through column chromatography (30% ethylacetate in hexane) to afford the title compound (yellow solid, 800 mg, 44%).

1. stirringstirring
2. extractionThe reaction mixture was extracted with ethylacetate and water
3. washwashed with brine
4. dry with materialThe washed organic layer was dried over sodium sulfate
5. concentrationconcentrated in a vacuum
6. custompurified through column chromatography (30% ethylacetate in hexane)