Methanesulfonyl chloride → HCID 18759097, compound

HRID 52723Notes

Reaction equation

HRID 52723 reaction equation
[OH:1][CH2:2][C:3]1[N:4]=[C:5]([CH:8]([CH3:10])[CH3:9])[S:6][CH:7]=1.C(N(C(C)C)CC)(C)C.[CH3:20][S:21](Cl)(=[O:23])=[O:22]>ClCCl>[CH:8]([C:5]1[S:6][CH:7]=[C:3]([CH2:2][O:1][S:21]([CH3:20])(=[O:23])=[O:22])[N:4]=1)([CH3:10])[CH3:9]

Participants

5

Reactant 3

HCID 31297Methanesulfonyl chlorideHCID 81531DiisopropylethylamineHCID 105349374-(Hydroxymethyl)-2-Isopropylthiazole

Product 1

HCID 18759097HCID 18759097, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 1.2 mmol of 4-(hydroxymethyl)-2-isopropylthiazole and 1.3 mmol of diisopropylethylamine in 20 ml of dichloromethane was cooled to -20° C. and treated dropwise with 1.3 mmol of methanesulfonyl chloride. The resulting mixture was stirred for 1 h, quenched with aqueous citric acid, separated, dried over Na2SO4, and concentrated in vacuo to provide the desired compound.

Workup

  1. customquenched with aqueous citric acid
  2. customseparated
  3. dry with materialdried over Na2SO4
  4. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-8200a8ddc57641b9bacedaa4d0145a5d
Source dataset
uspto-grants-1997_04
Patent number
US05616720

Reaction notes

Loading…