2-Methoxybenzoic acid → 5-((4-hydroxybenzyl)amino)-3-((4-(2-methoxybenzamido)phenyl)amino)-1H-pyrazole-4-carboxamide

HRID 527269Notes

Reaction equation

HRID 527269 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[C:13]([C:14]([NH2:16])=[O:15])=[C:12]([NH:17][CH2:18][C:19]3[CH:24]=[CH:23][C:22]([OH:25])=[CH:21][CH:20]=3)[NH:11][N:10]=2)=[CH:4][CH:3]=1.[C:26](O)(=[O:35])[C:27]1[C:28]([O:33][CH3:34])=[CH:29][CH:30]=[CH:31][CH:32]=1>CN(C=O)C>[OH:25][C:22]1[CH:23]=[CH:24][C:19]([CH2:18][NH:17][C:12]2[NH:11][N:10]=[C:9]([NH:8][C:5]3[CH:4]=[CH:3][C:2]([NH:1][C:26](=[O:35])[C:27]4[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=4[O:33][CH3:34])=[CH:7][CH:6]=3)[C:13]=2[C:14]([NH2:16])=[O:15])=[CH:20][CH:21]=1

Participants

4

Reactant 2

HCID 113702-Methoxybenzoic acidHCID 178513736HCID 178513736, compound

Product 1

HCID 1784895545-((4-hydroxybenzyl)amino)-3-((4-(2-methoxybenzamido)phenyl)amino)-1H-pyrazole-4-carboxamideYield 12%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent2×

Procedure

3-((4-aminophenyl)amino)-5-((4-hydroxybenzyl)amino)-1H-pyrazole-4-carboxamide (150 mg) was dissolved in 8.0 mL of DMF and TEA (183 μL, 3.0 eq.) was then added to the reaction vessel. Reaction was then stirred on an ice bath for 15 min and o-Anisic acid (67 mg, 1.00 eq.) dissolved in DMF (2.0 mL) was slowly added into the reaction. The reaction continued stirring for 18 hrs and allowed to reach room temperature. The reaction was tracked via HPLC, once completed and no traces of starting material is present, the solvent was then removed via vacuo and column chromatography was used to purify the compound. A gradient of 0 to 20% MeOH in dichloromethane was used and the desired fractions were combined, evaporated and triturated with diisoproyl ether then filtered to yield product as an off white powder (0.025 g, 12.0% yield).

Workup

  1. customReaction
  2. additionwas slowly added into the reaction
  3. stirringThe reaction continued stirring for 18 hrs
  4. customto reach room temperature
  5. customthe solvent was then removed via vacuo and column chromatography
  6. customto purify the compound
  7. customevaporated
  8. customtriturated with diisoproyl ether
  9. filtrationthen filtered

Sources & evidence

ORD record
ord-e51fd18147b34b7faf9fc2c816b393d1
Source dataset
uspto-grants-2016_05
Patent number
US09346792B2

Reaction notes

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